Scientists identified methylation of 24 regions, called CpG sites, in the DNA sequence, that interferes the effects of traffic-related particulate matter 2.5 (PM2.5) on brain structure changes in individuals with Alzheimer’s disease. DNA methylation is a biological process that adds chemical methyl groups to the DNA sequence. Some of the CpG sites locate in the […]
Outdoor PM2.5 poses risk of Alzheimer’s disesase to healthy elderly people
One, three, or five years of exposure to outdoor particulate matter 2.5 (PM2.5) increased the risk of developing Alzheimer’s disease among healthy elderly people. PM2.5 are inhalable air pollutant particles in diameter of 2.5 micrometers or less, which can be at least 20 times smaller than a human hair. Over years of urban development across […]
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5 Min
Probiotic Supplements Improved Cognitive Ability And Sleep Quality Of Elderly People With Mild Cognitive Impairment
Using probiotic supplements for 12 weeks improved cognitive ability and sleep quality of Chinese patients with mild cognitive impairment, a randomized controlled trial shows. Randomized controlled trials prospectively study how effective an intervention or a drug is on patients with a certain disease. It is the gold standard for effectiveness studies. People with mild cognitive impairment are […]
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7 Min
Gut Microbiome Changes in People with Preclinical Alzheimer’s Disease
People with preclinical Alzheimer’s disease have notably different gut microbiome features from those without the condition. The distinct gut microbiome features may help physicians detect preclinical Alzheimer’s early for individuals at risk. People with the preclinical condition have normal cognitive ability, while already show the biological evidence of Alzheimer’s in the brain, blood, or the […]
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5 Min
GFAP, a Strong Blood-based Biomarker, Predicted Alzheimer’s Disease at Least 10 Years Before Symptoms Appear
Researchers have found that by evaluating people’s blood levels of glial fibrillary acidic protein (GFAP), together with their cognitive test results and demographic information, they could predict Alzheimer’s disease at least 10 years before the diagnosis. The prediction was more accurate when they considered all these factors together, rather than considering the blood level of GFAP alone. […]
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6 Min
Weakened bones in women and chest pain in men are the top predictors of Alzheimer’s disease, a machine learning model shows
Researchers developed a machine learning model trained on a large amount of electronic health record data for finding risk factors that can predict Alzheimer’s disease. Machine learning model is a computer program that can find patterns in or make predictions about previously unseen data, after people trained it with a set of data. They identified weakened […]
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5 Min
GFAP Predicts Cognitive Worsening of Patients with Impaired Cognitive Ability
A cohort study of patients with impaired cognitive ability suggested that glial fibrillary acidic protein (GFAP), a potential blood-based biological marker, also called biomarker, can predict decline of cognitive ability associated with Alzheimer’s disease. This study showed the power of blood GFAP in predicting cognitive decline among patients with impaired cognitive ability. Current methods used […]
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5 Min
Increased Blood Levels of GFAP May Track Alzheimer’s Disease Progression Before Cognitive Symptoms Occur
In a study with people who had normal cognitive ability, researchers found that the blood levels of glial fibrillary acidic protein (GFAP) increased more rapidly in people at risk of future Alzheimer’s disease than those without the risk of the disease. Protein GFAP locates in the cells that support the nerve cells in the central […]
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5 Min
Six Months of Personalized Medicine Care Plan Improved Cognitive Ability in People with Mild Cognitive Impairment
Personalized medicine care plans improved cognitive ability of people with mild cognitive impairment significantly after six months, a study shows. The care plans modified the participants’ lifestyle, diet habits, and supplements intake, as well as prescription medications for their existing conditions. The findings suggest that a holistic, personalized medicine care plan can improve cognitive ability. […]
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5 Min