By using a machine learning-based model, researchers accurately predicted the person at early stage of Alzheimer’s disease would remain stable or progress over time. The team suggests this prediction tool is easier to scale up and has a strong potential to transition to clinics globally. This would also help clinicians make more accurate and timely decisions on […]
A cognitive decline prediction tool may provide the ideal time window for treating older adults at early stage of Alzheimer’s
Researchers in the Netherlands built a tool that could predict the time to a certain level of cognitive ability decline among people with mild cognitive impairment or mild dementia due to Alzheimer’s disease. They suggest that clinicians could use this tool to explain the expected natural decline of cognitive ability to patients. This could also help […]
Read Time:
9 Min
Short sleep duration affects the risk of dementia differently among older- and younger-older adults
Short sleep duration or sleeping less than seven hours each night linked to a higher risk of dementia onset among individuals aged 57-69, defined as younger-older adults. While, this linked to a lower risk of developing the condition among older-older adults aged 70 or older. Detecting this sleep pattern may help physicians or families identify […]
Read Time:
5 Min
Long hours of sleep protects against Alzheimer’s-related changes in the brain after three decades
For adults at their late 60s, over eight hours of sleep each night linked to a lower chance of developing the brain changes associated with Alzheimer’s disease 30 years later. This suggests that long sleep duration may prevent cumulative changes related to Alzheimer’s over decades in the brain of the elderly. Alzheimer’s is the most […]
Read Time:
6 Min
Gut microbiota change may be an early biomarker of Alzheimer’s for older adults with normal cognitive ability
By using systematic review method, scientists revealed that higher amount of two types of gut microbiota and a diverse microbiota composition link to better cognitive ability among cognitively healthy seniors. These findings suggest a future possibility of using gut microbiota as a biological marker for detecting Alzheimer’s before cognitive symptoms occur. Microbiota is consist of microorganisms, such […]
Read Time:
5 Min
Digital clock drawing test as a digital biomarker for early detection of Alzheimer’s disease
By using a digital clock drawing test, called DCTclockTM, researchers found that older adults with genetic risk of Alzheimer’s disease performed worse in the test than those without the risk. The genetic risk of Alzheimer’s in this study means that a person carries the APOE e4 gene or has a higher polygenic risk score. The findings suggest the potential of […]
Read Time:
8 Min
Good social connections lower the risk of mild cognitive impairment, dementia, and death among older adults
By using meta-analysis method, researchers found that social connections notably decreased the risk of mild cognitive impairment, dementia, and death among older adults globally. Social connections include interacting with family or friends, engaging in community activities, having a close or trusted friend, living conditions, relationship satisfaction, level of social support and loneliness. These findings suggest that middle-aged […]
Read Time:
5 Min
Blood-based biomarker p-tau217 may revolutionize the diagnosis of Alzheimer’s disease
Blood test of p-tau217 showed a similar or better ability in detecting Alzheimer’s disease-related structure changes in the brains of individuals with impaired cognitive ability, compared with cerebrospinal fluid test. The researchers suggest that p-tau217 blood test may replace positron emission tomography or cerebrospinal fluid test, the methods currently used in research and the clinic. […]
Read Time:
6 Min
DNA methylation mediates traffic-related PM2.5’s impact on Alzheimer’s disesase
Scientists identified methylation of 24 regions, called CpG sites, in the DNA sequence, that interferes the effects of traffic-related particulate matter 2.5 (PM2.5) on brain structure changes in individuals with Alzheimer’s disease. DNA methylation is a biological process that adds chemical methyl groups to the DNA sequence. Some of the CpG sites locate in the […]
Read Time:
5 Min
Outdoor PM2.5 poses risk of Alzheimer’s disesase to healthy elderly people
One, three, or five years of exposure to outdoor particulate matter 2.5 (PM2.5) increased the risk of developing Alzheimer’s disease among healthy elderly people. PM2.5 are inhalable air pollutant particles in diameter of 2.5 micrometers or less, which can be at least 20 times smaller than a human hair. Over years of urban development across […]
Read Time:
5 Min